TABLE 1.
Demographic and clinical characteristics of dementia with Lewy bodies (DLB) patients and healthy control subjects (HCS).
|
Characteristics |
Group | Statistic test, p | |
|---|---|---|---|
| DLB (n = 66) | HCS (n = 18) | ||
| Age (years) a | 70.24 (9.55) | 67.86 (7.93) | t = 0.966, p = 0.337 |
| Gender (M/F) | 26/40 | 9/9 | χ 2 = 0.655, p = 0.418 |
| Handedness (R/L) | 60/6 | 18/0 | χ 2 = 1.762, p = 0.184 |
| EL (years) a | 11.79 (4.03) | 13.67 (2.38) | U = 427.0, p = 0.067 |
| Stage of disease (pro/dem) | 47/19 | — | |
| MMSE score a | 26.30 (2.67) | 29.06 (0.96) | U = 201.0, p < 0.001 |
| Hallucinations (/9) a , b | 2.05 (2.16) | 0.11 (0.32) | U = 998.0, p < 0.001 |
| Fluctuations c , f | 6/18/17/19/6 | 12/5/1/0/0 | χ 2 = 31.392, p < 0.001 |
| Akinesia d , f | 28/35/3/0/0 | 17/1/0/0/0 | χ2 = 15.4, p < 0.001 |
| Rigidity d , f | 29/33/4/0/0 | 16/2/0/0/0 | χ 2 = 11.558, p = 0.003 |
| Tremor d , f | 60/6/0/0/0 | 16/2/0/0/0 | χ 2 = 0.067, p = 0.796 |
| RBD e , g | 20/19/27 | 12/5/1 | χ 2 = 10.217, p = 0.006 |
| MINI score a | 2.29 (3.18) | 0 (0) | |
| Psychotic phenomena (0/1) h | 47/19 | 18/0 | |
| Antidepressant (0/1) | 43/23 | 18/0 | |
| Antipsychotics (0/1) | 58/8 | 18/0 | |
| Acetylcholinesterase inhibitors (0/1) | 39/27 | 18/0 | |
| Dopamine enhancers (0/1) | 43/23 | 18/0 | |
Note: Significant p values (p < 0.05) are in boldface type.
Abbreviations: dem, mild dementia stage; DLB, dementia with Lewy bodies; EL, educational level; HCS, healthy control subjects; MINI, Mini International Neuropsychiatric Interview French version 5.0.0; MMSE, Mini‐Mental State Examination; pro, prodromal stage; RBD, rapid eye movement behaviour disorder.
Values are mean (SD).
According to [31].
According to [30].
According to the Unified Parkinson's Disease Rating Scale [32].
According to [33].
Rating from 0 to 4 (0/1/2/3/4).
Rating from 0 to 2 (0/1/2).
As measured by the fifth item of the hallucination scale [31].