Table 1.
Therapies targeting the metastatic cascade
| Drug name | Target | Drug type |
|---|---|---|
| Angiogenesis | ||
| Bevacizumab | VEGF | mAb |
| Ziv-Aflibercept | VEGFA, VEGFB | fusion protein |
| Ramucirumab | VEGF-R2 | mAb |
| Sorafenib | VEGF-R | small molecule |
| Pazopanib | VEGF-R | small molecule |
| Lenvatinib | VEGF-R | small molecule |
| Tivozanib | VEGF-R | small molecule |
| Ponatinib | VEGF-R | small molecule |
| Sunitinib | VEGF-R | small molecule |
| Regorafenib | VEGF-R | small molecule |
| Vandetanib | VEGF-R | small molecule |
| Epithelial mesenchymal transition | ||
| Cetuximab | EGFR | mAb |
| Erlotinib | EGFR | small molecule |
| Panitumumab | EGFR | mAb |
| NP137 | Netrin | mAb |
| Pritumumab | Vimentin | mAb |
| Migration and invasion | ||
| AT13148 | Rho | small molecule |
| Fasudil | Rho kinase | small molecule |
| Ketorolac | Rac1 | small molecule |
| Ulixertinib | ERK1/2 | small molecule |
| Trametinib | MEK | small molecule |
| Cobimetinib | MEK | small molecule |
| Binimetinib | MEK | small molecule |
| Intravasation | ||
| Rebastinib | TIE2 | small molecule |
| PLX7486 | CSF1R | small molecule |
| ARRY-382 | CSF1R | small molecule |
| RG7155 | CSF1R | mAb |
| FPA008 | CSF1R | mAb |
| Pexidartinib | CSF1R | small molecule |
| Immune invasion | ||
| Lirilumab | NK cell receptor | mAb |
| Monalizumab | NK cell receptor | mAb |
| AZD5069 | CXCR2 | small molecule |
| Pulmozyme | NET | DNase |
| Disulfiram | aldehyde dehydrogenase | small molecule |
| Pembrolizumab | PD1 | mAb |
| Sintilimab | PD1 | mAb |
| Nivolumab | PD1 | mAb |
| Toripalimab | PD1 | mAb |
| Atezolizumab | PD-L1 | mAb |
| Durvalumab | PD-L1 | mAb |
| Avelumab | PD-L1 | mAb |
| Ipilimumab | CTLA4 | mAb |
| Tremelimumab | CTLA4 | mAb |
| Colonization | ||
| Fresolimumab | TGF-β | mAb |
| Trabedersen | TGF-β | antisense oligonucleotide |
| Vigil | TGF-β | vaccine |
| Plerixafor | CXCR4 | small molecule |
| Denosumab | RANKL | mAb |
| Zoledronic acid | osteoclasts | bisphosphonate |
| Clodronate | osteoclasts | bisphosphonate |
| Pamidronate | osteoclasts | bisphosphonate |
| Uproleselan | E-selectin | small molecule |
| Prosaposin | Thrombospondin 1 | short peptide |
| Abemaciclib | CDK4/6 | small molecule |
| Anoikis resistance | ||
| Defactinib | FAK | small molecule |
| Ifebemtinib | FAK | small molecule |
| PND-1186 | FAK | small molecule |
| GSK2256098 | FAK | small molecule |
| Etaracizumab | αvβ3 | mAb |
| Cilengitide | integrins | small molecule |
| Conteltinib | integrins | small molecule |
| Extravasation | ||
| Heparin | P-selectin | polysaccharide |
| Eptifibatide | αIIbβ3 | small molecule |
| Tirofiban | αIIbβ3 | small molecule |
| Abciximab | αIIbβ3 | mAb |
Data are correct as of October 19, 2024; searches done by Ian Miranda.