Table 2.
CSF and PBMC cell type proportions in each of the four disease groups
| CSF | PBMC | |||||||
|---|---|---|---|---|---|---|---|---|
| Cell type | MS | NIND | OIND | ID | MS | NIND | OIND | ID |
| B cellsa | 3.2% (3.7) | 1.3% (1.8) | 2.6% (3.4) | 3.4% (4.1) | 6.7% (3.5) | 7.5% (2.9) | 6.6% (5.6) | 8.2% (7.1) |
| Plasma cells/ASCsa | 1.7% (2.1) | 0.2% (0.6) | 0.8% (1.1) | 1% (2.4) | 0.4% (0.4) | 0.3% (0.2) | 0.2% (0.5) | 0.9% (0.4) |
| mDCs | 1.3% (1.4) | 1.5% (1.3) | 2.3% (2.4) | 1.2% (1.9) | 0.6% (0.6) | 0.4% (0.4) | 0.4% (0.6) | 1% (0.4) |
| HSPCs | 0% (0) | 0% (0) | 0% (0) | 0% (0) | 0.1% (0.1) | 0.1% (0.1) | 0.1% (0.1) | 0.2% (0.1) |
| CD14 mono | 2.7% (2.5) | 4% (4.2) | 4.5% (5.1) | 2.5% (1.6) | 10.8% (7.9) | 8.1% (4.8) | 7.7% (7.3) | 15.4% (6.1) |
| CD16 mono | 0% (0) | 0% (0.1) | 0% (0) | 0% (0) | 1.6% (1.5) | 1.6% (1.6) | 1.2% (1) | 1.5% (0.4) |
| Macrophages | 0.2% (0.5) | 1.2% (1.2) | 0.4% (0.5) | 0.1% (0.1) | 0% (0) | 0% (0) | 0% (0) | 0% (0) |
| CD4+ T cells | 58% (13.7) | 59.8% (9) | 52.1% (15.3) | 45.6% (17.9) | 52.7% (14.4) | 54.5% (13.5) | 58.2% (6.6) | 42.9% (6.4) |
| CD8+ T cells | 20.1% (8) | 21.5% (7.6) | 17.7% (14.5) | 22.7% (9.8) | 10.3% (5.3) | 13.8% (7.4) | 12.6% (8.2) | 12.7% (1) |
| Tregs | 3.8% (2.8) | 4.2% (2.2) | 4.2% (3.8) | 6% (4.7) | 1.8% (1.3) | 2.3% (1.2) | 2.5% (1.8) | 1.2% (0.4) |
| MAIT cells | 0.7% (0.7) | 0.8% (0.9) | 0.8% (0.9) | 0.8% (1.4) | 1.5% (1.3) | 1.3% (1.4) | 1% (1.1) | 1.5% (2) |
| NK cells | 4.3% (2.4) | 3.5% (2.1) | 3.8% (3.8) | 6.1% (4.4) | 7.8% (6.3) | 6.5% (3.4) | 6.6% (3.3) | 9.4% (5.5) |
| pDCs | 0.6% (1) | 0.3% (0.9) | 0.8% (1) | 0.7% (1) | 0.2% (0.2) | 0.2% (0.2) | 0.1% (0.2) | 0.3% (0.1) |
Values represent the median % of the total PBMC/CSF cell population in each disease cohort (i.e., the percentage of the PBMC/CSF cell population was calculated per person, and then the median was taken across the cohort). The values in brackets represent the interquartile range. Only subjects with >10 total cells in the relevant compartment (PBMC or CSF) were included in these calculations.
a
Indicates the two cell types—B cells and plasma cells/ASCs—which were present at higher proportions in MS CSF compared with NIND CSF at a false discovery rate of <1%.