Table 3. Comparison of known Drosophila cG-PDEs with vertebrate cG-PDEs.
Data from Figures 5–7 are tabulated to aid comparison with vertebrate homologues of Drosophila PDEs. Values for Km (cGMP and cAMP) and IC50 values for zaprinast and sildenafil are listed, where known, with appropriate references. ND, not determined.
| Enzyme | Km cGMP (μM) | Km cAMP (μM) | IC50 zaprinast (μM) | IC50 sildenafil (μM) |
|---|---|---|---|---|
| Drosophila PDE1 | 15.3±1 | 20.5±1.5 | 71±39 | 1.3±0.9 |
| PDE1C | 2.2±0.1 (Mouse [43]) | 3.5±0.3 (Mouse [43]) | 3.5±0.6 (Human [44]) | 1.1±0.275 (Bovine aorta PDE1 [45]) |
| Drosophila PDE6 | 37±13 | ND | 0.65±0.15 | 0.025±0.005 |
| PDE6β | 17±7 (Bovine [46]) | ND | 0.18±0.01 {Human (Ki) [47]} | 0.02±0.001 (Human (Ki) [47]) |
| Drosophila PDE11 | 6±2 | 18.5±5.5 | 1.6±0.5 | 0.12±0.06 |
| PDE11A | 0.52±0.34 (Human PDE11A1 [48]) | 1.04±0.23 (Human PDE11A1 [48]) | 12 (Human PDE11A1 [48]) | 3.8±0.75 (Human PDE11A4 [49]) |