Table 3.
Univariate and multivariate Cox regression analysis of various factors for predicting OS in the training cohort.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | 0.076 | |||
| ≤ 35 | Reference | NA | ||
| > 35 | 1.168 (0.984–1.388) | NA | ||
| Gender | 0.004 | 0.921 | ||
| Male | Reference | Reference | ||
| Female | 0.783 (0.662–0.925) | 0.921 (0.774–1.096) | ||
| Race | 0.008 | 0.014 | ||
| White | Reference | Reference | ||
| Black | 1.005 (0.792–1.275) | 0.894 (0.689–1.144) | ||
| Other1 | 0.711 (0.567–0.893) | 0.707 (0.560–0.893) | ||
| Marital status | < 0.001 | 0.008 | ||
| Married | Reference | Reference | ||
| Others2 | 1.354 (1.145–1.601) | 1.269 (1.064–1.514) | ||
| Side | 0.888 | |||
| Left | Reference | NA | ||
| Right | 0.981 (0.822–1.169) | NA | ||
| Bilateral | 0.923 (0.666–1.281) | NA | ||
| Primary site | < 0.001 | 0.1 | ||
| Main bronchus | 1.175 (0.758–1.821) | 1.383 (0.882–2.168) | ||
| Upper lobe | 0.478 (0.261–0.877) | 0.630 (0.340–1.168) | ||
| Middle lobe | 0.897 (0.573–1.404) | 1.181 (0.747–1.865) | ||
| Lower lobe | 2.078 (1.061–4.068) | 2.517 (1.271–4.984) | ||
| Overlapping lesion | 1.216 (0.772–1.916) | 1.572 (0.987–2.503) | ||
| Lung NOS | Reference | Reference | ||
| Histological type | < 0.001 | 0.036 | ||
| Adenocarcinoma | Reference | Reference | ||
| Squamous | 2.052 (1.509–2.791) | 1.502 (1.088–2.072) | ||
| Others3 | 1.128 (0.985–1.508) | 1.125 (0.906–1.396) | ||
| T stage | ||||
| T0 | Reference | < 0.001 | Reference | < 0.001 |
| T1 | 4.174 (1.013–17.176) | 5.796 (1.395–24.087) | ||
| T2 | 4.828 (1.192–19.554) | 6.151 (1.503–25.174) | ||
| T3 | 5.583 (1.381–22.571) | 6.339 (1.550–25.920) | ||
| T4 | 6.913 (1.717–27.834) | 9.158 (2.225–37.282) | ||
| N stage | < 0.001 | 0.001 | ||
| N0 | Reference | Reference | ||
| N1 | 1.139 (0.929–1.837) | 1.405 (0.978–2.017) | ||
| N2 | 1.557 (1.229–1.971) | 1.540 (1.198–1.979) | ||
| N3 | (1.171–1.935) | 1.677 (1.287–2.186) | ||
| M stage | 0.157 | |||
| M1a | Reference | NA | ||
| M1b | 1.223 (0.992–1.506) | NA | ||
| M1NOS | 1.170 (0.702–1.949) | |||
| Bone metastasis | 0.067 | NA | ||
| No | Reference | |||
| Yes | 1.170 (0.989–1.383) | NA | ||
| Brain metastasis | 0.133 | NA | ||
| No | Reference | |||
| Yes | 0.873 (0.733–1.041) | NA | ||
| Liver metastasis | < 0.001 | < 0.001 | ||
| No | Reference | Reference | ||
| Yes | 1.519 (1.244–1.854) | 1.474 (1.202–1.806) | ||
| Lung metastasis | 0.405 | NA | ||
| No | Reference | |||
| Yes | 1.077 (0.905–1.281) | NA | ||
| Chemotherapy | <0.001 | < 0.001 | ||
| No | Reference | Reference | ||
| Yes | 0.617 (0.500–0.761) | 0.531 (0.424–0.666) | ||
| Radiotherapy | <0.001 | < 0.001 | ||
| No | Reference | Reference | ||
| Yes | 1.343 (1.134–1.591) | 1.445 (1.212–1.724) | ||
Other1: American Indian, AK Native, Asian or Pacific Islander.
Others2: Unmarried or Domestic Partner, Single (never married), Widowed, Divorced, Separated
Others3: Mucoepidermoid carcinoma, Mucinous adenocarcinoma, Synovial sarcoma.