Other names |
– |
– |
Variable number tandem repeats (VNTRs) |
Short tandem repeats (STRs) |
Size of repeat unit |
5 to several hundred bases |
Mainly “TTAGGG”' in humans |
6 to > 50 bp |
1 to 5 bp |
Total expansion size |
100 kb to several Mb |
10–15 kb |
100 bp to ∼ 20 kb |
10 to ∼100 bp (excluding certain trinucleotide repeats) |
Location |
Heterochromatin, especially centromeric heterochromatin |
All telomeres |
Throughout genome, but most clustered in telomeric regions |
Distributed almost ubiquitously throughout genome |
Biological functions |
Unknown (probably none) |
Protects chromosome ends, provides means of terminal sequence replication, possible roles in chromosome pairing and cell ageing |
Very rare examples of expression, importance unknown. Otherwise unknown (probably none) |
Unknown, but may fine tune gene expression. Again trinucleotides are special case. (Contingency genes in prokaryotes) |