Table 1.

Summary of the relation between E2 gene disruption, histological diagnosis, and interphase cytogenetic data

		Chromosome number
Diagnosis	Karyotype	1	3	11	17	18	X	Non-amplifying Segment(s)
CIN 3	Aneusomic	4	4	3	3	3	5	None
CIN 3	Aneusomic	2	2	2	2	3	4	None
CIN 3	Tetrasomic	4	4	4	4	4	4	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	None
CIN 3	Disomic	2	2	2	2	2	2	B, C
ISCC	Aneusomic	2	2	2	2	2	1	None
ISCC	Aneusomic	3	3	3	3	3	5	None
ISCC	Tetrasomic	4	4	4	4	4	4	None
ISCC	Aneusomic	4	2	4	4	2	4	None
ISCC	Aneusomic	4	3	1	3	4	4	None
ISCC	Aneusomic	2	3	2	2	2	3	None
ISCC	Aneusomic	3	4	2	2	2	4	B
ISCC	Aneusomic	4	4	4	3	4	5	B
ISCC	Disomic	2	2	2	2	2	2	A, B, C
ISCC	Disomic	2	2	2	2	2	2	B, C
ISCC	Aneusomic	2	2	3	2	2	3	A
ISCC	Aneusomic	3	3	2	2	2	3	A, B
ISCC	Disomic	2	2	2	2	2	2	A
ISCC	Disomic	2	2	2	2	2	2	A, B

The data for each chromosome refer to the number of chromosomes identified, as reported previously.¹⁸

The definitions of aneusomic, tetrasomic, and disomic are given in the text.

CIN 3, cervical intraepithelial neoplasia grade 3; ISCC, invasive squamous cell carcinoma.