Figure 1.
The promoter region of the latent membrane protein 1 (LMP-1) gene, from position −320 to +41, relative to the transcription start site. The sequence of B95.8 is shown in full.11 For group D and CAO only mutated nucleotides are shown.15 The sequences of groups A–C are not shown because these isolates only contained one single base mutation compared with B95.8. The recognition sequences and/or binding sites of the transcription factors are marked with a line.28,32–34 CREB indicates the activating transcription factor/cAMP response element (ATF/CRE) (−38 to −45), which binds ATF-1/CREB-1 heterodimers.28