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. 2000 Oct;53(5):280–288. doi: 10.1136/mp.53.5.280

Figure 3.

Figure 3

The amino acid sequence of the B95.8 latent membrane protein 1 (LMP-1) is shown in full.11 For our group A–D variants and CAO-LMP-1 only mutated amino acids are shown.15 The CAO-LMP-1 gene contains seven 11 amino acid repeats and our group B/C isolates contained from three to seven 11 amino acid repeats in the repeat region. In this figure only four are shown. Amino acid substitutions in the transmembrane domain suggested by Miller and colleagues29 to increase NF-κB activation are at positions 86, 106, 122, 128, and 129. The HLA-A2 restricted cytotoxic T cell epitopes are marked with a double line: the cytotoxic T cell epitope eliciting a strong responce at amino acids 125 to 133 and the cytotoxic T-cell epitope eliciting a weak response at amino acids 159 to 167.30 The C-terminal activation regions 1 (CTAR-1) and CTAR-2, and the recently identified CTAR-3, are indicated by a single line.35–40 The five amino acid (15 bp) deletion in the repeat region and the 10 amino acid (30 bp) deletion in the C-terminus are marked by asterisks.