Table 3.

The circRNAs that regulate EZH2.

circRNA	Cancer	Effect
circRNA sponges upstream miRNA of EZH2
circ_0071589	Colorectal cancer	circ_0071589 promotes EZH2 expression by sponging miR-600, promoting colorectal cancer growth, invasion, and migration.27
circ_0115744	Colorectal cancer	circ_0115744, as a competitive endogenous RNA of miR-144, weakens the inhibitory effect on its target EZH2.28
circ_PRMT5	Non-small cell lung cancer	circ_PRMT5 simultaneously sponges miR-377, miR-382, and miR-498, attenuating their inhibition of EZH2.29
circ_PRDM2	Osteosarcoma	circ_PRDM2 regulates EZH2 positively by sponging miR-760, promoting the resistance of osteosarcoma to doxorubicin.30
circ_0020123	Non-small cell lung cancer	circ_0020123 up-regulates EZH2 through competitive binding with miR-144.31
circ-TRPS1	Pancreatic carcinoma	circ-TRPS1 enhances EZH2 expression by sponging miR-124–3p, promoting pancreatic carcinoma progression.32
circ_ANKIB1	Osteosarcoma	circ_ANKIB1 binds to miR-26b-5p and regulates EZH2, accelerating the chemical resistance of osteosarcoma.33
circ_0026123	Ovarian cancer	circ_0026123 promotes EZH2 expression through sponging miR-124–3p.34
circ_SYPL1	Hepatocellular carcinoma	circ_SYPL1 sponges miR-506–3p to increase EZH2 expression.35
circRNA binds to EZH2
circ-LRIG3	Hepatocellular carcinoma	circ-LRIG3 form ternary complexes with EZH2 and STAT3 that promotes EZH2-induced STAT3 methylation and subsequent phosphorylation, leading to activation of STAT3 signaling.36
circ_000623	Laryngeal squamous cell cancer	circ_ 0006232 promotes EZH2 expression through interaction with Fused in sarcoma.37
circ_0019435	Cervical cancer	EZH2 was recruited to inhibit the transcription of dickkopf1 and phosphatase and tensin homolog, promoting cervical cancer cell proliferation, invasion, and epithelial–mesenchymal transition.38

EZH2, enhancer of zeste homolog 2; STAT3, signal transducer and activator of transcription 3.