Figure 2.

In situ hybridisation screening of colon cancers. The representative clones are shown, and the names identified by sequencing are indicated below. The signals were detected in cancer cells for selected clones such as integrin α6 (A), p97 (C), and thymosin β4 (E) with each antisense probe. In contrast, signals were detected in interstitial cells, but not in cancer cells, for collagen type I (G) with the antisense probe. Hybridisation signals were absent on consecutive sections treated with sense probes (B, D, F, and H). Original magnification, ×10. AS, antisense; S, sense.