Table 3.

Allele frequencies for four factor VIII gene polymorphisms frequently used in linkage studies in haemophilia A

			Frequency
Location	Name	Alleles	Whites	Japanese	Chinese	American blacks
Intron 18	BclI	+	0.76	0.70	0.82	0.20
		–	0.24	0.30	0.18	0.80
Intron 19	HindIII	+	0.25		0.24	0.78
		–	0.75		0.76	0.22
Intron 22	XbaI A	+	0.58	0.59	0.57
		–	0.42	0.41	0.43
Intron 25	BglI	+	0.90	0.91	1	0.74
		–	0.10	0.09	0	0.26

Source references, white: Bcl1,⁵⁹ HindII,⁵⁹ Xbal A,⁴² Bgl1,⁴⁵; all Japanese data⁶⁰; Chinese: Bcl1,⁶¹ HindIII,⁵⁹ Xba1,⁶¹; American black: Bcl1,⁵⁹ HindII,⁵⁹ and Bgl1.⁴⁵