Table 2.
Effect of allocation to higher dose corticosteroid on key study outcomes.
| Treatment allocation |
RR (95% CI) | ||
|---|---|---|---|
| Higher dose steroids (n = 246) | Usual care (n = 231) | ||
| Primary outcome | |||
| 28-day mortality | 86 (35%) | 86 (37%) | 0.87 (0.64–1.18) |
| Secondary outcomes | |||
| Time to being discharged alive, days (median [IQR]) | 24 (12 to >28) | 26 (11 to >28) | |
| Discharged from hospital within 28 days | 128 (52%) | 120 (52%) | 1.04 (0.81–1.33) |
| Receipt of invasive mechanical ventilation or deatha | 76/206 (37%) | 93/205 (45%) | 0.79 (0.63–1.00) |
| Invasive mechanical ventilation | 29/206 (14%) | 40/205 (20%) | 0.72 (0.46–1.11) |
| Death | 65/206 (32%) | 79/205 (39%) | 0.80 (0.62–1.04) |
| Subsidiary clinical outcomes | |||
| Successful cessation of invasive mechanical ventilationb | 14/40 (35%) | 11/26 (42%) | 0.80 (0.36–1.80) |
| Use of haemodialysis or haemofiltrationc | 21/243 (9%) | 18/229 (8%) | 0.97 (0.54–1.74) |
Data are n (%) or n/N (%), unless otherwise indicated. RR = rate ratio for the outcomes of 28-day mortality and hospital discharge, and risk ratio for other outcomes. CI = confidence interval. Estimates of the RR and its 95% CI are adjusted for age in three categories (<70 years, 70–79 years, and 80 years or older) and ventilation status at randomisation in two categories (non-invasive ventilation and invasive mechanical ventilation).
a
Analyses exclude those on invasive mechanical ventilation at randomisation.
b
Analyses restricted to those on invasive mechanical ventilation at randomisation.
c
Analyses exclude those on haemodialysis or haemofiltration at randomisation.