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The expression of ADAM12 mRNA in giant cell tumour tissues. (A) Positive signal for ADAM12 mRNA detected by in situ hybridisation; the brown granules are seen in the cytoplasm of multinucleated giant cells (thick arrow) and in some mononuclear stromal cells (thin arrow). (B) Negative ADAM12 mRNA control using a nonsense probe. Original magnification, ×200.
