Table 3.

Summary of various mutations seen in 30 carcinomas of the ampulla of Vater

Patient	Increased cyclin D1 expression	Intracellular β catenin expression	CTNNB-1 mutation	k-ras mutation (codon 12)
1	−	−	WT	GGT to GAT (Gly to Asp)
2	−	−	WT	GGT to GTT (Gly to Val)
3	−	−	WT	WT
4	−	−	WT	WT
5	−	−	WT	WT
6	−	−	WT	WT
7	−	−	WT	WT
8	−	−	WT	WT
9	−	−	WT	WT
10	−	−	WT	WT
11	−	−	WT	WT
12	−	−	WT	WT
13	−	−	WT	WT
14	+	−	WT	GGT to GAT (Gly to Asp)
15	+	−	WT	GGT to GAT (Gly to Asp)
16	+	−	WT	GGT to GAT (Gly to Asp)
17	+	−	WT	GGT to GAT (Gly to Asp)
18	+	−	WT	GGT to GTT (Gly to Val)
19	+	−	WT	WT
20	+	−	WT	WT
21	+	−	WT	WT
22	+	+	Codon 37 TCT to TTT (Ser to Phe)	GGT to GTT (Gly to Val)
23	+	+	Codon 37 TCT to TGT (Ser to Cys)	WT
24	+	+	Codon 41 ACC to GCC (Thr to Ala)	WT
25	+	+	Codon 45 TCT to CCT (Ser to Pro)	GGT to GAT (Gly to Asp)
26	+	+	WT	GGT to GAT (Gly to Asp)
27	+	+	WT	GGT to GAT (Gly to Asp)
28	+	+	WT	GGT to GTT (Gly to Val)
29	+	+	WT	WT
30	+	+	WT	WT

WT, wild-type gene.