Table 2. Optimization of the cross-coupling.
| ||
|---|---|---|
| # | Deviations from stand. cond. | Y. of 3,a (%) |
| 1 | None | 92 (91)b |
| 2 | Open to air | 87 |
| 3 | 455 nm LED | 82 |
| 4 | 4CzIPN as PC (455 nm LED) | 80 |
| 5 | Without DME | 76 |
| 6 | L2 as the ligand | 76 |
| 7 | No phthalimide | 64 |
| 8 | No NiCl2·diglyme | 0 |
| 9 | No L1 | <5 |
| 10 | No PC | <5 |
| 11 | No light | 0 |
Determined by 1H NMR with CH2Br2 as an internal standard.
Isolated yield.