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. 2024 Oct 22;15(1):526–541. doi: 10.1016/j.apsb.2024.10.006

Figure 4.

Figure 4

In vitro anti-tumor activity of HFn@Fe/siGPX4. (A) In vitro cell viability of MCF-7 cells after 48 h of exposure to siGPX4, HFn@siGPX4 and HFn@Fe/siGPX4 at different concentrations of siGPX4. (B) In vitro cell viability of MCF-7 cells after 48 h of exposure to Fe, HFn@Fe and HFn@Fe/siGPX4 at different concentrations of Fe. (C) The ATP level in MCF-7 cells of different groups. (D) Flow cytometry analysis of MCF-7 cell apoptosis induced by siGPX4, HFn@siGPX4, and HFn@Fe/siGPX4 NPs for 48 h using Annexin VFITC/PI staining. (E) Fluorescence images of Calcein-AM/PI. Scale bar = 100 μm. Data are presented as mean ± SD (n = 3). ∗∗∗∗P < 0.0001.