Table 1.
Pharmacokinetic parameters of BST and AG in NRs and physical mixture formulations (free BST-AG) after i.v. injection in rats at a BST dose of 5 mg/kg and AG dose of 15 mg/kg.
| Parameter | t1/2 (h) | AUC0-∞ (h·μg/mL) | MRT0‒∞ (h) | Vd (L/kg) | CL (L/h/kg) |
|---|---|---|---|---|---|
| Free BST | 1.40 ± 0.1 | 4.07 ± 2.1 | 1.62 ± 0.4 | 1.99 ± 0.3 | 1.22 ± 0.3 |
| BST-NRs | 2.16 ± 0.4∗∗ | 14.19 ± 3.4∗∗∗ | 2.80 ± 0.6∗∗ | 0.98 ± 0.5∗∗ | 0.35 ± 0.2∗∗ |
| Free AG | 1.84 ± 0.3 | 18.76 ± 5.6 | 2.41 ± 0.7 | 1.93 ± 0.4 | 0.79 ± 0.1 |
| AG-NRs | 3.21 ± 0.5∗∗∗ | 43.94 ± 7.3∗∗∗ | 3.76 ± 0.6∗ | 1.29 ± 0.5ns | 0.34 ± 0.1∗∗∗ |
AUC, the area under the curve; MRT, mean residence time; CL, clearance rate; Vd, volume of distribution. The data are given as mean ± SD, n = 6. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, compared to the free groups. ns, not significant.