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Mean pharmacokinetic parameters of 14l in SD rats after single drop administration of 14l eye drops at a dose of 16 μg/eye (n = 3).
| PK parameter | Cmax (ng/g) | Tmax (h) | T1/2 (h) | Tlast (h) | AUC0‒t (h·ng/g) | AUC0‒∞ (h·ng/g) |
|---|---|---|---|---|---|---|
| Meibomian glands | 2732.66 | 1.00 | 4.32 | 24.00 | 14379.61 | 14670.67 |
| Cornea | 3052.49 | 1.00 | 1.11 | 4.00 | 4339.41 | 4567.46 |
| Conjunctiva | 358.02 | 0.25 | 1.30 | 4.00 | 489.73 | 564.99 |
| Retina | NDa | NDa | NDa | NDa | NDa | NDa |
| Blood | NDa | NDa | NDa | NDa | NDa | NDa |
ND: not detected.
