Table 3.
Co-sibling analyses of preterm delivery or hypertensive disorders of pregnancy and subsequent risk of type 2 diabetes.
| Type 2 diabetes cases | Adjusted HR (95% CI)a | |
|---|---|---|
| Up to 46 years after delivery | ||
| Preterm delivery (<37 wks) | 9,066 | 1.31 (1.24, 1.38) |
| Early term (37–38 wks) | 19,437 | 1.14 (1.10, 1.19) |
| Full-term (39–41 wks) | 37,752 | Reference |
| Hypertensive disorders | 9,307 | 1.65 (1.56, 1.73) |
| No hypertensive disorders | 59,147 | Reference |
| <10 years after delivery | ||
| Preterm delivery (<37 wks) | 2,445 | 2.25 (1.59, 3.18) |
| Early term (37–38 wks) | 4,318 | 1.24 (0.97, 1.59) |
| Full-term (39–41 wks) | 4,933 | Reference |
| Hypertensive disorders | 1,889 | 1.47 (1.01, 2.13) |
| No hypertensive disorders | 9,993 | Reference |
| 10–19 years after delivery | ||
| Preterm delivery (<37 wks) | 2,379 | 1.64 (1.34, 2.01) |
| Early term (37–38 wks) | 5,011 | 1.24 (1.07, 1.43) |
| Full-term (39–41 wks) | 7,417 | Reference |
| Hypertensive disorders | 2,014 | 2.10 (1.69, 2.61) |
| No hypertensive disorders | 13,218 | Reference |
| 20–29 years after delivery | ||
| Preterm delivery (<37 wks) | 2,650 | 1.46 (1.30, 1.64) |
| Early term (37–38 wks) | 6,142 | 1.21 (1.12, 1.32) |
| Full-term (39–41 wks) | 12,306 | Reference |
| Hypertensive disorders | 2,880 | 1.50 (1.34, 1.68) |
| No hypertensive disorders | 19,283 | Reference |
| 30–46 years after delivery | ||
| Preterm delivery (<37 wks) | 1,592 | 1.10 (1.00, 1.21) |
| Early term (37–38 wks) | 3,966 | 1.03 (0.96, 1.10) |
| Full-term (39–41 wks) | 13,096 | Reference |
| Hypertensive disorders | 2,524 | 1.65 (1.51, 1.81) |
| No hypertensive disorders | 17,812 | Reference |
a
Adjusted for shared familial (genetic and/or environmental) factors, and additionally for maternal age, year of delivery, parity, education, employment, income, country of origin, BMI, smoking, pre-existing hypertension or hyperlipidemia, gestational diabetes, and other adverse pregnancy outcomes.