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. 1969 Feb;111(3):325–332. doi: 10.1042/bj1110325

Synthesis of 10,11-dihydrofarnesyl pyrophosphate from 6,7-dihydrogeranyl pyrophosphate by prenyltransferase

G Popják 1,*, P W Holloway 1,†, J M Baron 1
PMCID: PMC1187515  PMID: 4304159

Abstract

The syntheses of 6,7-dihydrogeraniol and of its pyrophosphate are described. It is shown that this analogue of geranyl pyrophosphate is a substrate for liver prenyltransferase and that the product synthesized by this enzyme from it and isopentenyl pyrophosphate is 10,11-dihydrofarnesyl pyrophosphate. The Km value for 6,7-dihydrogeranyl pyrophosphate was determined to be 1·11±0·19μm as compared with 4·34±1·71μm for geranyl pyrophosphate. The maximum reaction velocity with the artifical substrate was, however, only about one-fourth of that observed with geranyl pyrophosphate. The binding of isopentenyl pyrophosphate to the enzyme was not affected by the artificial substrate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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