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[Preprint]. 2025 Feb 21:rs.3.rs-6049325. [Version 1] doi: 10.21203/rs.3.rs-6049325/v1

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Comparison of lipid-dependent intersubunit interactions in different gating states of rTRPV2 (A) and rTRPV1 (B) at various temperatures. The detergent-induced cryo-EM structures of the PE-dependent rTRPV2 channel in the 3^rd and 4^th closed, open, and partially open states at 4 °C (PDB ID, 8EKR, 5HI9, 6BO4 and 6BO5, respectively) were used for model A. The capsaicin-induced cryo-EM structures of the PI-dependent rTRPV1 channel in the 1^st and 2^nd closed, open, and inactivated states from 4 °C to 48 °C (PDB ID, 8GF9, 7LPB, 7LPE and 7LPD/7LP9, respectively) were used for model B.