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[Preprint]. 2025 Feb 21:rs.3.rs-6049325. [Version 1] doi: 10.21203/rs.3.rs-6049325/v1

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Temperature-dependent gating pathways of rTRPV2. The homo-tetrameric cryo-EM structures of rTRPV2 in the 3^rd and 4^th closed, open and partially open states in different detergents at 4 °C (PDB ID, 8EKR, 5HI9, 6BO4 and 6BO5, respectively) were used for the model. The partially open state also functions as a partially inactivated state. The corresponding biggest thermorings Grid₁₂, Grid₁₉, Grid_12’ and Grid₁₄ are colored red, respectively. All the least-stable noncovalent interactions controlled by those biggest thermorings are indicated by red space fill. The intersubunit interactions are indicated by green space fill.