Reagents and tools table
| Reagent/Resource | Reference or Source | Identifier or Catalog Number |
|---|---|---|
| Experimental models | ||
| AsPC-1 (H. sapiens) | ATCC | CRL-1682 |
| Additional pancreatic cancer cell lines | See Appendix Table S1 | See Appendix Table S1 |
| Pancreatic patient-derived organoids | See Appendix Table S2 | See Appendix Table S2 |
| Chemicals, Enzymes and other reagents | ||
| Elimusertib | Selleckchem | S8666 |
| Gartisertib | Selleckchem | S9639 |
| Ceralasertib | Selleckchem | S7693 |
| Berzosertib | Selleckchem | S7102 |
| Gemcitabine | Selleckchem | S1714 |
| Oxaliplatin | Selleckchem | S1224 |
| Cisplatin | Selleckchem | S1166 |
| 5-Fluorouracil | Selleckchem | S1209 |
| Additional compounds used in viability screen | See Dataset EV1 | See Dataset EV1 |
| TMT10plex Isobaric Label Reagent Set | Thermo Fisher Scientific | 90406 |
| TMT11-131C Labeling Reagent | Thermo Fisher Scientific | A34807 |
| TMTpro 16plex Label Reagent Set | Thermo Fisher Scientific | A44520 |
| DMEM | PAN Biotech | P04-04510 |
| RPMI | PAN Biotech | P04-18500 |
| DMEM/Hams-F12 (1:1) | PAN Biotech | P04-41154 |
| Fetal Bovine Serum | PAN Biotech | P04-18500 |
| HEPES | PAN Biotech | P05-01100 |
| Non Essential Amino Acid Solution | PAN Biotech | P08-32100 |
| Bovine Pituitary Extract | Thermo Fisher Scientific | 13028014 |
| Recombinant human EGF protein | R&D Systems | 236-EG |
| Keratinocyte-free medium | Thermo Fisher Scientific | 17005042 |
| Penicillin Streptomycin GlutaMAX | Thermo Fisher Scientific | A5873601 |
| Reagents used for patient-derived organoids | See Appendix Table S3 | See Appendix Table S3 |
| ATPlite 1step Luminescence Assay System | revvity, previously Perkin Elmer | 6016731 |
| CellTiter-Glo Luminescent Cell Viability Assay | Promega | G7572 |
| Software | ||
| MaxQuant (v1.6.12.0, v2.1.3.0) | Cox and Mann (2008) | |
| Perseus (v1.6.2.3) | Tyanova et al (2016) | |
| SIMSI-Transfer (v0.5.0) | Hamood et al (2022), https://github.com/kusterlab/SIMSI-Transfer | |
| CurveCurator (v0.4.1) | Bayer et al (2023), https://github.com/kusterlab/curve_curator | |
| PTMnavigator | Müller et al (2025), https://www.proteomicsdb.org/analytics/ptmNavigator | |
| Other | ||
| Dionex UltiMate 3000 RSLCnano System | Thermo Fisher Scientific | |
| Fusion Lumos Tribrid mass spectrometer | Thermo Fisher Scientific | |
| Janus Gripper | revvity, previously Perkin Elmer | |
| Multidrop Combi Reagent Dispenser | Thermo Scientific | |
| Incucyte S3 | Sartorius | |
| Envision Xcite 2104 plate reader | revvity, previously Perkin Elmer | |
| Spark Multimode microplate reader | TECAN | |
| VantaSTAR | BMG Labtech | |