Table 1. Optimization of Conditions for the Chalcone Synthesis (1 mmol scale)^a.

			Yield (%)b
Entry	Solvent/Surfactant	Base	3a	4a
144	EtOH	NaOH	59	8
2	H2O	NaOH	70	0
3	CTABc	NaOH	56	11
4	CTABd	NaOH	65	9
5	CTABe	NaOH	61	8
6	CTABd	KOH	62	9
7	CTABd	K2CO3	64	10
8	CTABd	KOtBu	64	9
9	CTABd	DBUf	34	15
10	CTABd	DABCOg	49	4
11	CTABd	Piperidine	44	3
12	CTABd	TEAh	57	5
13	CTABd	C12H25(CH3)2N	-	-

^aReaction conditions: 5 mL vial, benzaldehyde (1 mmol), acetophenone (1 mmol), base (1 mmol); CTAB solution (1 mL), rt, 24 h.

^bThe yields were estimated by ¹H NMR with heptane as internal standard.

^c(at CMC; 0.9 mM, 0.033%).

^d(5 × CMC; 0.0045 M, 0.16%).

^e(61 × CMC; 54.9 mM, 2%).

^f1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU).

^g1,4-Diazabicyclo[2.2.2]octane (DABCO).

^hTriethylamine (TEA).