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. 2025 Feb 18;90(8):2915–2926. doi: 10.1021/acs.joc.4c02616

Table 2. Optimization of the Surfactant for Chalcone Synthesis (1 mmol scale) with NaOH as the Basea.

    Yield (%)b
Entry Surfactant (2%) 3a 4a
1 CTAB 61 8
2 SDS 83 0
3 TPGS 77 0
4 PTS 78 0
5 Nok 75 0
6 Brij 35 80 1
7 Triton X-100 76 0
8 Kolliphor EL 76 0
9 Tween 80 85 0
a

Reaction conditions: 5 mL vial, benzaldehyde (1 mmol), acetophenone (1 mmol), NaOH (base) (1 mmol); surfactant solution (1 mL), rt, 24 h.

b

The yields were estimated by 1H NMR with heptane as an internal standard.