Table 2. Optimization of the Surfactant for Chalcone Synthesis (1 mmol scale) with NaOH as the Basea.
| Yield
(%)b |
|||
|---|---|---|---|
| Entry | Surfactant (2%) | 3a | 4a |
| 1 | CTAB | 61 | 8 |
| 2 | SDS | 83 | 0 |
| 3 | TPGS | 77 | 0 |
| 4 | PTS | 78 | 0 |
| 5 | Nok | 75 | 0 |
| 6 | Brij 35 | 80 | 1 |
| 7 | Triton X-100 | 76 | 0 |
| 8 | Kolliphor EL | 76 | 0 |
| 9 | Tween 80 | 85 | 0 |
Reaction conditions: 5 mL vial, benzaldehyde (1 mmol), acetophenone (1 mmol), NaOH (base) (1 mmol); surfactant solution (1 mL), rt, 24 h.
The yields were estimated by 1H NMR with heptane as an internal standard.