Skip to main content
. 2025 Feb 18;90(8):2915–2926. doi: 10.1021/acs.joc.4c02616

Table 6. Representative Chalcone Synthesis (1 mmol scale) in CTAB and Tween 80a.

      Isolated Yieldb (%)
Entry Compound T (°C) CTAB Tween 80
1 9 25 63 (11) 4
2 10c 25 1 7
3 10d 45 25 29
4 11 25 30 -
5 11 45 30 (4) -
6 12 25 44 14
7 13 25 23 12
8 13 45 15 8
9 14 25 72 (15) 88 (7)
10 15 25 71 (19) 38 (24)
11 16 25 51 34
12 17 25 69 (2) 91
a

Reaction conditions: 5 mL vial, benzaldehyde (1 mmol), acetophenone (1 mmol), NaOH (base) (1 equiv); surfactant solution (1 mL), rt or 45 °C, 24 h.

b

Isolated yield (Michael in parentheses).

c

NaOH (2 equiv).

d

NaOH (4 equiv).