Table 1. Optimization of the Acylation of Ferrocene with Unprotected Glycine.
| entry | TFAA eq | acyl trifluoroacetate generation time min | reaction time h | 3a | 4 | % of reacting Fc-H |
|---|---|---|---|---|---|---|
| 1 | 2 | 15 | 1 | 17% | 46% | 97% |
| 2 | 2 | 30 | 1 | 21% | 45% | 94% |
| 3 | 2 | 30 | 4 | 25% | 45% | 96% |
| 4 | 3 | 30 | 1 | 26% | 44% | 94% |