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. 2025 Feb 18;90(8):2958–2968. doi: 10.1021/acs.joc.4c02717

Table 1. Optimization of the Acylation of Ferrocene with Unprotected Glycine.

entry TFAA eq acyl trifluoroacetate generation time min reaction time h 3a 4 % of reacting Fc-H
1 2 15 1 17% 46% 97%
2 2 30 1 21% 45% 94%
3 2 30 4 25% 45% 96%
4 3 30 1 26% 44% 94%