Table 1:
Summary of characteristics of the Pick’s disease series and controls.
| Variable | N | Median (25th percentile, 75th percentile) or No. (%) (N=338) |
|---|---|---|
| Pick’s disease series | ||
| Age at death (years) | 69 (65, 74) | |
| Age of disease onset (years) | 58 (54, 65) | |
| Disease duration (years) | 10 (8, 13) | |
| Sex | ||
| Male | 205 (60.7%) | |
| Female | 133 (39.3%) | |
| Clinical diagnosis | 328 | |
| FTD | 262 (79.9%) | |
| AD | 40 (12.2%) | |
| CBS | 15 (4.6%) | |
| PSP | 2 (0.6%) | |
| Dementia not otherwise specified | 8 (2.4%) | |
| Vascular dementia | 1 (0.3%) | |
| Behavioral impairment during illness | 232 | 188 (81.0%) |
| Language impairment during illness | 221 | 153 (69.2%) |
| Parkinsonism during illness | 206 | 56 (27.2%) |
| Braak NFT stage | 176 | |
| 0 | 87 (49.4%) | |
| I | 29 (16.5%) | |
| II | 28 (15.9%) | |
| III | 11 (6.3%) | |
| IV | 10 (5.7%) | |
| V | 4 (2.3%) | |
| VI | 7 (4.0%) | |
| Thal amyloid phase | 177 | |
| 0 | 100 (56.5%) | |
| 1 | 32 (18.1%) | |
| 2 | 18 (10.2%) | |
| 3 | 15 (8.5%) | |
| 4 | 7 (4.0%) | |
| 5 | 5 (2.8%) | |
| Brain weight (g) | 296 | 980 (880, 1083) |
| Controls | ||
| Age at blood draw (years) | 69 (61, 75) | |
| Sex | ||
| Male | 611 (46.6%) | |
| Female | 701 (53.4%) |
FTD=frontotemporal dementia; bvFTD=behavioral variant FTD; PPA=primary progressive aphasia; AD=Alzheimer’s disease; CBS=corticobasal syndrome; PSP=progressive supranuclear palsy; VaD=vascular dementia; NFT=neurofibrillary tangle.
Age at disease onset and disease duration information was not available for 29 individuals in the Pick’s disease series.