Table 2.
Ancestral duplications in different functional categories of eukaryotic genesa
| Functional class | P(χ2) details | Number of KOGs in the largest cluster | Largest cluster |
|---|---|---|---|
| Translation | 7 × 10−4 (excess of size two clusters; deficit of larger clusters) | 4 | EF2 |
| Replication and repair | 0.1 (no difference) | 6 | Cdc46/Mcm |
| Transcription | 0.2 (no difference) | 16 | HOX |
| Cytoskeleton | 0.2 (no difference) | 22 | Profilin superfamily |
| Chaperones and related proteins involved in protein fate determination | 2.7 × 10−3 (excess of duplications) | 30 | RINGs |
| Signal transduction | 0.99 (no difference) | 39 | S/T kinases |
| Energy metabolism | 3 × 10−4 (deficit of duplications) | 21 | Mitochondrial carrier protein |
| Secretion | 0.2 (no difference) | 22 | Profilin-like proteins |
| RNA processing and modification | 0.26 (no difference) | 31 | RRM |
aThe rough functional classification of eukaryotic genes was adopted from the KOG database (47).