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The top 10 ‘frozen’ ancestral paralogous clusters in eukaryotes
| Cluster description | Number of KOGs in cluster | Inferred origin |
|---|---|---|
| WD-40 | 93 | Bacterial |
| HEAT/ARM | 34 | Bacterial |
| TPR | 28 | LUCA |
| RRM (RNA-binding) | 26 | Bacterial |
| RINGs | 21 | Eukaryotic |
| Helicases | 17 | LUCA |
| snRNP-like | 15 | LUCA |
| SNARE-like proteins | 14 | Eukaryotic |
| PINT domains | 14 | Eukaryotic |
| C2H2-type Zn-fingers | 14 | Eukaryotic |
