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. 2005 Aug 18;115(9):2393–2401. doi: 10.1172/JCI25437

Figure 6.

Figure 6

Anti-NGF and a p38 MAPK inhibitor suppress cold hyperalgesia and TRPA1 upregulation in the spared L4 DRG neurons caused by injury to the L5 spinal nerve. (A) Dark-field photomicrograph of ISHH showing the expression of TRPA1 and TRPM8 mRNA in the naive DRG, the injured L5 DRG, and the intact L4 DRG at day 7 after L5 SNL. (B) Cold hyperalgesia was determined using the cold plate test at days 3 and 7 after L5 SNL. Data represent mean ± SEM; n = 8 per group. (C and D) Quantification of the percentage of TRPA1 (C) and TRPM8 (D) mRNA–positive neurons at day 7 after surgery. Data represent mean ± SD; n = 4 per group. *P < 0.05 compared with the naive control; #P < 0.05 compared with the vehicle group. Scale bar: 100 μm.