Figure 3.

Modulation of membrane capacitance by serosal addition of purinergic receptor agonists. (A and B) ATP or the following ATP agonists were added at a final concentration of 50 μM to the serosal surface of isolated rabbit uroepithelium without exposure to pressure changes: ATPγS, 2MeSATP, benzoyl ATP (BzATP), UTP, ADP, or 2MeSADP. The inset in A shows a dose-response curve for the change in capacitance recorded 300 minutes after addition of the specified concentration of ATPγS. Data are shown as mean changes in capacitance ± SEM (n ≥ 3). *Statistically significant difference (P < 0.05) relative to untreated control preparations.