Fig. 5.

The inhibitory effect of CXCL11 on osteoclastogenesis is independent of CCR5. (A) Identification of monocytes heterozygous (lane B) or homozygous (lane C) for the CCR5 Δ32 mutation. Lanes: A, wild type; D, molecular weight marker in base pairs. (B and C) Inhibitory activity of CXCL11 (B), IFN-α2(C, gray bars) and IFN-β (C, black bars) on osteoclastic differentiation of monocytes homozygous for the CCR5 Δ32 mutation. Cellular differentiation assay and analysis were performed as for Figs. 1 and 4.