Table 1.
Studies included in the meta-analysis analyzing MMP8 and aMMP8 levels in patients with periodontitis and healthy controls.
| Author, reference nr. | Publication year | Country | Measured parameter | Saliva sampling method | Method of measurement | Unit of measurement |
|---|---|---|---|---|---|---|
| Rai et al. (41) | 2008 | India | MMP8 | Unstimulated | ELISA | ng/ml |
| Mirrielees et al. (42) | 2010 | USA | MMP8 | Unstimulated | ELISA | ng/ml |
| Buduneli et al. (43) | 2011 | Türkiye | MMP8 | Stimulated | IFMA | ng/ml |
| Rathnayake et al. (46) | 2013 | Sweden | MMP8 | Stimulated | ELISA | ng/ml |
| Ebersole et al. (44) | 2013 | USA | MMP8 | Unstimulated | ELISA | ng/ml |
| Meschiari et al. (45) | 2013 | Brazil | MMP8 | Stimulated | ELISA | ng/ml |
| Miricescu et al. (47) | 2014 | Romania | MMP8 | Unstimulated | ELISA | ng/mg albumin |
| Gupta et al. (50) | 2015 | India | MMP8 | Unstimulated | ELISA | ng/ml |
| Ebersole et al. (49) | 2015 | USA | MMP8 | Unstimulated | Millipore | ng/ml |
| Akbari et al. (48) | 2015 | India | MMP8 | Unstimulated | ELISA | ng/ml |
| Martinez et al. (52) | 2017 | Sweden | MMP8 | Unstimulated | ELISA | ng/ml |
| Lira-Junior et al. (51) | 2017 | Türkiye | MMP8 | Unstimulated | ELISA | ng/ml |
| Rangbulla et al. (53) | 2017 | India | MMP8 | Unstimulated | ELISA | ng/ml |
| Golitsyna et al. (54) | 2018 | Russia | MMP8 | Not reported | ELISA | ng/ml |
| Sharma et al. (55) | 2018 | India | MMP8 | Unstimulated | ELISA | ng/μl |
| Aungurencei et al. (56) | 2019 | Romania | MMP8 | Not reported | ELISA | ng/ml |
| Fastovets et al. (57) | 2020 | Ukraine | MMP8 | Not reported | ELISA | mkg/L |
| Fatemi et al. (58) | 2020 | Iran | MMP8 | Unstimulated | ELISA | ng/ml |
| Lee et al. (59) | 2020 | South Korea | MMP8 | Unstimulated | ELISA | ng/ml |
| Lira-Junior et al. (62) | 2021 | United Kingdom | MMP8 | Unstimulated | ELISA | ng/ml |
| Bostanci et al. (61) | 2021 | Türkiye | MMP8 | Unstimulated | ELISA | ng/ml |
| Al Jasser et al. (60) | 2021 | Saudi Arabia | MMP8 | Unstimulated | ELISA | ng/ml |
| Zhang et al. (63) | 2021 | China | MMP8 | Stimulated | ELISA | ng/ml |
| Balaji et al. (64) | 2022 | India | MMP8 | Unstimulated | ELISA | pg/ml |
| Wu et al. (65) | 2022 | China | MMP8 | Not reported | ELISA | NA |
| Noack et al. (66) | 2017 | Germany | aMMP8 | Both | ELISA | ng/ml |
| Raisanen et al. (15) | 2019 | Finland | aMMP8 | Not Reported | IFMA | ng/ml |
| Heikkinen et al. (67) | 2019 | Finland | aMMP8 | Stimulated | Not Reported | μg/L |
| Sorsa et al. (10) | 2020 | Finland | aMMP8 | Not Reported | IFMA | ng/ml |
| Yucel et al. (68) | 2020 | Türkiye | aMMP8 | Unstimulated | IFMA | ng/ml |
| Ozturk et al. (69) | 2021 | Türkiye | aMMP8 | Not Reported | IFMA | ng/μl |
| Ramenzoni et al. (70) | 2021 | Switzerland | aMMP8 | Both | ELISA | ng/ml |
| Deng et al. (71) | 2022 | China | aMMP8 | Unstimulated | Lateral flow immunoassay | ng/ml |
| Umeizudike et al. (21) | 2022 | United Kingdom | aMMP8 | Unstimulated | IFMA | ng/ml |
| Yilmaz et al. (72) | 2023 | Türkiye | aMMP8 | Unstimulated | IFMA | ng/ml |