Appendix 1.

Search Strategy using MeSH and TIAB.

Aspect	MeSH + TIAB	Comments
MMP-8	"Matrix Metalloproteinase 8"[Mesh] OR “Matrix Metalloproteinase 8"[tiab] OR “MMP 8”[tiab] OR “MMP8”[tiab] OR “MMP-8"[tiab] OR "Neutrophil Collagenase"[tiab] OR “PMN Collagenase"[tiab] OR “Collagenase 2"[tiab] OR “CLG1"[tiab] OR	"EC 3.4.24.34"[tiab]
Diagnosis accuracy/prediction	"Diagnosis"[Mesh] OR “Biomarkers"[Mesh] OR “diagnosis"[Subheading] OR “diagnos*”[tiab] OR “Early Detect*”[tiab] OR Predict*[tiab] OR “Identif*”[tiab] OR “Recognition”[tiab] OR “Screening”[tiab] OR “Confirmatory Test*”[tiab] OR “Clinical Assessment*”[tiab] OR biomarker*[tiab] OR marker*[tiab] OR indicator*[tiab]	"Early Diagnosis"[Mesh] OR
Gingivitis OR periodontal inflammation	"Gingivitis"[Mesh] OR “Gingivitis, Necrotizing Ulcerative"[Mesh] OR Gingiviti*[tiab] OR “Gingiva inflam*”[tiab] OR “Gingival inflam*”[tiab] OR “Gingival Infection”[tiab] OR “Gingival Swelling”[tiab] OR Gingival Erythema”[tiab] OR “Gum Dis*”[tiab] OR “Gum Infection”[tiab] OR “Gum Swelling”[tiab] OR “Gum Redness”[tiab] OR “Gum Inflam*”[tiab] OR “Inflammation of gum tissue” [tiab] OR “Inflamed Gum*”[tiab] OR “Swollen Gum*”[tiab] OR “Inflammation of the Periodontium” [tiab] OR “Periodontitis”[tiab] OR “Periodontal Dis*”[tiab] OR “Periodontal Tissue Dis*”[tiab] OR “Periodontal Tissue Infect*”[tiab] OR “Periodontal Tissue Inflam*”[tiab] OR “Periodontitis”[tiab] OR “Periodontal Swelling”[tiab] OR “Periodontal Inflam*”[tiab] OR “Periodontal Infect*”[tiab] OR “Periodontal Erythema”[tiab] OR