Table 1. Amino acids that, on average, contribute 50% of the interprotein interaction potential for two- and four-chain systems.

Amino acid	Amino acid identity	Buried in lowest-energy structure
1	K	No
2	E	No
22	L	Yes
25	I	Yes
26	D	No
33	I	Yes
35	K	No
37	K	No
54	M	Yes
55	I	Yes