Table 1. Average of mutation frequencies (±SD) ×10–4 in hybridoma transfectants.
| V
|
|||||
|---|---|---|---|---|---|
| Cell lines | AID+ | AID– | Intron | Cμ | hAID |
| Sp6 | 10.9 ± 3.3 (45/40,914) | <1.6 (0/6,368) | ND | 0.5 (2/32,046) | 5.3 ± 0.1 (13/24,395) |
| WT | 15.5 ± 2.0 (70/44,676) | 1.5 (1/6,801) | ND | ND | ND |
| Eμ | 2.0 ± 1.9 (29/49,889) | <0.7 (0/15,357) | <0.8 (0/13,010) | ND | 4.4 ± 1.3 (13/29,199) |
| MARs-μ+ | 1.0 ± 0.7 (4/36,835) | 0.9 ± 1.6 (2/20,407) | ND | ND | 6.1 (± 6.5) (13/11,437) |
| MAR-μ– | 1.1 ± 1.0 (4/35,357) | 0.8 ± 1.6 (1/12,974) | ND | ND | ND |
| Δ-μ+ | 13.0 ± 4.8 (80/60,161) | <0.6 (0/15,928) | 1.3 ± 1.9 (1/6,127) | 2.2 ± 1.9 (12/50,068) | 11.4 ± 6.1 (13/11,437) |
| Δ-μ– | <1.0 (0/28,789) | <0.8 (0/12,613) | ND | ND | ND |
Averages of mutation frequency are of several hAID (V AID+, Intron, Cμ, and hAID) or pCEP (V AID–) transfectants. Values in parentheses indicate mutations/bases sequenced. ND, not determined.