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. 2024 Oct 14;62(4):4115–4138. doi: 10.1007/s12035-024-04533-6

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© The Author(s) 2024

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Fig. 8 — Docking results for the interaction of 4-CmC and salicylate with the central domain of hRyR2 and hRyR3. A 4-CmC forms a hydrogen bond with Gln3975 residue, and engages in hydrophobic interaction with other six residues (Ile4013, Val4010, Leu4014, Val4098, Val3979, Leu3948) in the central domain of hRyR2. B Salicylate forms a hydrogen bond with Gln3975 residue, and engage in hydrophobic interaction with other four residues (Val4098, Met3978, Leu3948, Val3979) in the central domain of hRyR2. C 4-CmC forms an adverse interaction with Gln3872 of RyR3, and just engage in hydrophobic interaction with Trp3786. D Salicylate forms a hydrogen bond with Gln3872 and engage in hydrophobic interaction with Trp3786 in the central domain of hRyR3