Table 2.

Working Memory Task change in the BOLD signal for each region of interest pre-post lithium The change in each region of interest is shown for the working memory task (mean ± SEM). There are three treatment groups: healthy controls, euthymic bipolar patients, and depressed bipolar patients. Significant differences (and trends towards significant differences) between patient group and controls are shown as are significant differences (and trends towards significant differences) between euthymic bipolar patients and depressed bipolar patients.

Region of interest	Bipolar Euthymic Mean ± SEM	Bipolar Depressed Mean ± SEM
Cingulate gyrus	0.03 ± 0.12	-0.19 ± 0.12
Left dorsolateral prefrontal cortex	0.27 ± 0.14	0.03 ± 0.26
Right dorsolateral prefrontal cortex	-0.04 ± 0.05	-0.14 ± 0.22
Left inferior parietal gyrus	-0.15 ± 0.21	-0.10 ± 0.11
Right inferior parietal gyrus	-0.09 ± 0.18	-0.13 ± 0.17
Left precentral gyrus	-0.03 ± 0.29	0.10 ± 0.10
Right precentral gyrus	0.09 ± 0.14	-0.03 ± 0.05
Left superior parietal gyrus	-0.16 ± 0.23	-0.08 ± 0.23
Right superior parietal gyrus	-0.12 ± 0.23	-0.04 ± 0.11
Left inferior frontal gyrus	0.06 ± 0.31	0.02 ± 0.20
Right inferior frontal gyrus	0.10 ± 0.10	0.17 ± 0.15
Left insula	-0.03 ± 0.07	0.18 ± 0.15
Right insula	0.15 ± 0.11	0.08 ± 0.17
Left middle frontal gyrus	0.25 ± 0.17	0.36 ± 0.13
Right middle frontal gyrus	0.17 ± 0.31	-0.10 ± 0.20
Left superior frontal gyrus	0.04 ± 0.23	-0.28 ± 0.09
Right superior frontal gyrus	0.29 ± 0.27	0.03 ± 0.23
Left inferior occipital gyrus	0.31 ± 0.22	0.39 ± 0.26
Right inferior occipital gyrus	0.06 ± 0.18	0.19 ± 0.18