Homologous sequences search on any NCBI-formatted database including nr, Swissprot and Ensembl. |
Homologous sequences search limited to Swissprot and trEMBL. |
Homologous sequences search on any NCBI-formatted database including nr. |
Choice of the scope of phylomes by the user (root = all phylomes by default) |
No choice of the scope of phylomes by the user. |
Choice of the scope of phylomes by the user. |
Automatic detection of domains on the query sequence. |
Manual input of a domain that must be present in pfam and for which pairwise distances must have been precalculated. |
Phylogenetic reconstruction at BLAST's high scoring pairs (HSPs) level converted after corrections in multiple sequence alignment (MSA). |
Expert system selection of domains and repeats whose evolutionary behaviour are congruent. |
Phylogenetic reconstruction on a single domain provided by the user. |
No test for domains congruence. Phylogenies constructed on a corrected alignment with a HMM profile. |
When no domain is found phylogenetic reconstruction on the "alignable" portion of the query sequence. |
No reconstruction possible when no known domain is present on the query sequence. |
Phylogenetic reconstruction possible regardless the presence of a known domain on the query sequence. |
Elimination of sites not evolving under neutral evolution. |
No elimination of sites producing biases in phylogenetic reconstruction. |
No elimination of sites producing biases in phylogenetic reconstruction. |
Elimination of sequences having a divergent amino acids composition |
No elimination of sequences with divergent composition. |
No test for sequence composition but selection for sequences producing significant alignments with the query HMM. |
Phylogenetic reconstruction with three different methods and projection on a consensus tree. |
Phylogenetic reconstruction with one single method (NJ). |
Choice of reconstruction method (NJ by default) but only one method at a time and no fusion with multiple methods. |
Comparison of the consensus tree with NCBI reference tree of life containing around 200,000 taxa. |
Comparison of the NJ tree with a reference tree of life containing around 2,500 taxa. |
Comparison of the one-method tree with NCBI reference tree of life containing around 200,000 taxa. |
Automatic detection of speciation and duplications, of orthologs and paralogs. |
Automatic detection of speciation and duplications, of orthologs and paralogs. |
Functionality not available. Possibility to scan a database of trees for a given topology. |
Automatic extraction of experimentally verified functional information for all detected orthologs and paralogs. |
Functionality not available |
Functionality not available |