Table 2.
Tumor | Antigen | HLA allele | Peptide sequence* | Reference |
Synovial sarcoma | SYT-SSX (SSX1,2,4) | A24 | PYGYDQ/IMPK | 38 |
A24 | GYDQ/IMPKK | 38,61 | ||
A24 | GYDQ/IMPKI | 40 | ||
B7 | QRPYGYDQ/IM | 48 | ||
Ewing sarcoma | EWS-FLI1 (type 1) | A3, A31, B44 | SSSYGQQN/PSYDSVRRGA | 49 |
EWS-FLI1 (type 2) | A2, A3, A24, B7, B44, B62 | SSSYGQ/QSSLLAYNT | 49 | |
Alveolar rhabdomyosarcoma | PAX3-FKHR | A33, A68, B7 | TIGNGLSPQ/NSIRHNLSL | 49 |
Osteosarcoma | Papillomavirus binding factor | B55 | CTACRWKKACQR | 17 |
Peptide sequences shown to induce cytotoxic T lymphocites or those used in clinical trials are listed. Slash indicates the breakpoint.