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. 2025 Feb 13;22(3):1408–1418. doi: 10.1021/acs.molpharmaceut.4c01117

Figure 2.

Figure 2

(a) SLE phase diagram of the API (1)/hydrotrope (2)/water (3) system at 305 K assuming different values of the API–water binary interaction parameter (A13) and A12 = −0.5 and A23 = −0.5, calculated using the Two-Suffix Margules model. (b) Corresponding (x1/x0) value calculated along the solubility isotherm at 305 K for different A13 values. (c) Corresponding (γ1/γ0) value calculated along the solubility isotherm at 305 K for different A13 values. (d) API solubility enhancement factor (Φ) at (x2 = 0.5) for different solution temperatures and varying values of the API–water binary interaction parameter (A13) and A12 = −0.5 and A23 = −0.5.