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. 2025 Feb 13;22(3):1408–1418. doi: 10.1021/acs.molpharmaceut.4c01117

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© 2025 The Authors. Published by American Chemical Society

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(a) SLE phase diagram of the API (1)/hydrotrope (2)/water (3) system at 305 K assuming different values of the hydrotrope–water binary interaction parameter (A₂₃) and A₁₂ = −0.5 and A₁₃ = +0.5, calculated using the Two-Suffix Margules model. (b) Corresponding (x₁/x₀) value calculated along the solubility isotherm at 305 K for different A₂₃ values. (c) Corresponding (γ₁/γ₀) value calculated along the solubility isotherm at 305 K for different A₂₃ values. (d) API solubility enhancement factor (Φ) at (x₂ = 0.5) for different solution temperatures and varying values of the hydrotrope–water binary interaction parameter (A₂₃) and A₁₂ = −0.5 and A₁₃ = +0.5.