Table 3:

Univariate and multivariable analyses examining the association between demographic and clinical variables and the development of MAKE-90 in children with sepsis requiring CRRT.

Variable	Univariate Analysis (n=393)			Multivariable Analysis (n=393)
	MAKE-90 (n=260)	No-MAKE-90 (n=133)	p	aOR	95% CI	p
Age, years	11 (3–16)	7 (2–13)	0.031*	1.04	1.0–1.07	0.06
Sex, female (%)	124 (48)	61 (46)	0.73
Admission Diagnosis, n (%)			<0.001*
Shock/Infection/Major Trauma	127 (49)	99 (74)		Ref	--	--
Respiratory Failure	60 (23)	11 (8)		3.12	1.50–6.47	0.002
CNS Dysfunction	12 (5)	2 (2)		5.84	1.19–28.6	0.029
Primary Cardiac	22 (9)	3 (2)		4.54	1.27–16.2	0.020
Other	39 (15)	18 (14)		1.63	0.82–3.25	0.16
Comorbidities, yes (%)	227 (87)	83 (63)	<0.001*	2.81	1.55–5.09	<0.001
Baseline Serum Creatinine, mg/dl	0.40 (0.23–0.65)	0.48 (0.35–0.62)	0.036*	0.78	0.48–1.28	0.33
Known Baseline, yes (%)	168 (65)	52 (39)	<0.001*	1.95	1.18–3.22	0.009
PRISM III	14 (11–19)	16 (11–21)	0.18
PELOD-2 at CRRT Initiation	6 (3–10)	6 (3–8)	0.49
VIS at CRRT Initiation	10 (0–26)	6 (0–27)	0.50
Time from ICU Admission to CRRT, days	2 (1–8)	2 (1–4)	0.22
%Fluid Balance from ICU Admission to CRRT	9 (4–20)	11 (4–24)	0.21
Initial CRRT Modality			0.94
CVVH, n (%)	25 (9.6)	15 (11)
CVVHD, n (%)	24 (9.2)	13 (9.8)
CVVDHF, n (%)	206 (79)	104 (78)
mCVVH, n (%)	2 (0.8)	0 (0)
SCUF, n (%)	3 (1.2)	1 (0.8)
Vasoactive Change 1st 48h CRRT			0.009*
Never/Decreased, n (%)	197 (76)	116 (87)		0.61	0.32–1.18	0.14
Unchanged/Increased, n (%)	62 (24)	17 (13)		Ref	--	--
Percentage of Day 1–7 of CRRT Requiring Vasoactives	50 (13–100)	38 (0–76)	0.006*	1.01	1.00–1.01	0.016
CRRT Dose Day 1–2, ml/kg	43 (32–58)	44 (32–60)	0.74
CRRT Dose Day 1–7, ml/kg	43 (33–59)	45 (32–60)	0.92
Time to First Negative Fluid Balance, days	1 (0–1)	1 (0–1)	0.77
Median Fluid Balance Day 1–2, ml/kg/day	−6 (−19,7)	−7 (−21,10)	0.60
Median Fluid Balance Day 1–7, ml/kg/day	−4 (−13,3)	−7 (−16,4)	0.087*	1.00	1.00–1.00	0.80

Continuous variables reported as median (IQR).

^*Variables with p<0.15 on univariate analysis were included in the multivariable model, which also adjusted for center using mixed-effects logistic regression.

Abbreviations: PRISM III- Pediatric Risk of Mortality III score; PELOD-2- Pediatric Logistic Organ Dysfunction 2 score; VIS- vasoactive-inotropic score; CRRT- continuous renal replacement therapy; CVVH- continuous veno-venous hemofiltration; CVVHD- continuous veno-venous hemodialysis; CVVHDF- continuous veno-venous hemodiafiltration; mCVVH- modified continuous veno-venous hemofiltration; SCUF- slow continuous ultrafiltration