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. 2025 Feb 7;69(3):e01736-24. doi: 10.1128/aac.01736-24

TABLE 3.

Distribution of BMD results for the ATM–CZA combination for the 61 study isolates that tested non-susceptible to both ATM and CZA individually, as categorized by their β-lactamase genotype

Organisms β-Lactamasea Totalb ATM–CZA susceptibility by BMD
S (%) R (%)
Enterobacterales MBL 28 26 (92.9) 2 (7.1)
Non-MBL 7 4 (57.1) 3 (42.9)
Total 35 30 (85.7) 5 (14.3)
P. aeruginosa MBL 5 0 5 (100)
GES 8 3 (37.5) 5 (62.5)
Non-MBL, non-GES 6 0 6 (100)
Total 19 3 (15.8) 16 (84.2)
S. maltophilia L1 7 6 (85.7) 1 (14.3)
All organisms 61 39 (64) 22 (36)
a

MBL, metallo-beta-lactamase; GES, Guiana extended-spectrum beta-lactamase.

b

Non-susceptible to ATM alone and CZA alone.