Table 2.

Revised European Society for Blood and Marrow Transplantation criteria for diagnosis of SOS/VOD (2023)

Probable	Clinical	Proven
Two of the following criteria must be present	Bilirubin ≥2 mg/dl and two of the following criteria must be present	Histologically proven SOS/VOD or hemodynamically proven (HVPG ≥10 mm Hg)
• Bilirubin ≥2 mg/dl	• Painful hepatomegaly
• Painful hepatomegaly	• Weight gain >5%
• Weight gain >5%	• Ascites
• Ascites
• Ultrasound and/or elastography suggestive of SOS/VOD
Onset
In the first 21 d after HSCT: classical SOS/VOD	>21 d after HSCT: late onset SOS/VOD

For any patient, these symptoms/signs should not be attributable to others causes. HSCT, hematopoietic stem cell transplant; HVPG, hepatic venous pressure gradient; SOS/VOD, sinusoidal obstruction syndrome/veno-occlusive disease.

Ref. 63.