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. 2025 Feb 20;13:1552716. doi: 10.3389/fcell.2025.1552716

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Copyright © 2025 Britton, Somogyi-Leatigaga, Watson, Haro, Mulder, Kennedy, Cooper, Whitley, Yeboah, Kim, Yu, Campos, Amoah, Kawauchi, Kim, Pira and Oberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Twelve conserved non-coding DNA regions within the Lhx2 locus are suitable candidates for potential cis-regulatory modules. Conserved (Cons.) non-coding DNA regions in the Lhx2 locus were found to be associated with enhancer-related chromatin modification marks–H3K4me2, H3K27ac, p300, RNAP2, and Med12 – and thus potential cis-regulatory modules (PCRMs). PCRMs located upstream of the Lhx2 promoter were given a negative number and PCRMs located downstream were given a positive number. Location of active CNEs described by Lee and colleagues (Lee et al., 2011) are marked by black triangles. CRM (-8) and CRM (-9), located within the Dennd1a gene, are highlighted in yellow since they showed enhancer activity in the distal limb.