Fig. 1.

Tertiary structure of the JD of ataxin-3. (A) Stereoview of the superimposed Cα backbone traces of the 20 lowest-energy calculated structures. Traces are rainbow-colored, with the N terminus (N) in red and the C terminus (C) in blue. Numbers and corresponding small filled circles indicate residue multiples of 20. (B) Ribbon diagram of a representative structure from A shown in the same orientation. The left lobe (blue) comprises a six-stranded β-sheet and two α-helices. The right lobe (red) comprises only α-helices.