Table 2.
Enrichment of essential phenotypes in C. elegans orthologs of human sociability-linked genes, including and excluding the srsx gene family
| Includes srsx gene family | Phenotype | Proportion in total protein-coding genome | Proportion in sociability orthologs | OR (95% CI) | p-Value |
|---|---|---|---|---|---|
| Yes | Lethal | 0.09 | 0.17 | 0.51 [0.26–1.08] | 0.507 |
| Embryonic lethal | 0.15 | 0.21 | 0.66 [0.36–1.29] | 0.168 | |
| Larval lethal | 0.04 | 0.05 | 0.90 [0.29–4.49 | 0753 | |
| Sterile | 0.12 | 0.18 | 0.62 [0.33–1.28] | 0.131 | |
| Sterile progeny | 0.04 | 0.02 | 2.42 [0.42–97.11] | 0.733 | |
| No | Lethal | 0.09 | 0.19 | 0.42 [0.22–0.91] | 0.018* |
| Embryonic lethal | 0.15 | 0.25 | 0.54 [0.29–1.08] | 0.061 | |
| Larval lethal | 0.04 | 0.05 | 0.77 [0.25–3.86] | 0.509 | |
| Sterile | 0.12 | 0.21 | 0.51 [0.27–1.08] | 0.063 | |
| Sterile progeny | 0.04 | 0.02 | 2.08 [0.36–83.87] | 0.724 |
OR odds ratio, CI confidence interval
*Significant at alpha = 0.05